Abstract Human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer type in the world and is associated with an overall poor prognosis. The protein methyltransferase SET and MYND domain-containing 3 (SMYD3). which trimethylates H3K4. activates gene transcription and enhances several oncogenic pathways. https://tftoyes.shop/product-category/rudolph-the-red-nosed-reindeer/