Topological entanglements are abundant. and often detrimental. in polymeric systems in biology and materials science. Here we theoretically investigate the topological simplification of knots by diffusing slip-links (SLs). https://www.roneverhart.com/Jelly-Belly-Sparkling-Rose-Jelly-Beans-1-5-Ounce-Bottles-24-Piece-Box/