Abstract Regulatory T cells play a crucial role in orchestrating immune response and maintaining immune tolerance. and the expression of the Foxp3 gene is indispensable to the differentiation of regulatory T cells. IL-4 shows strong inhibitory effects on Foxp3 expression and regulatory T cells differentiation. but the detailed mechanisms are still unclear. https://www.nacrack.com/hot-find-892-Renegade-8-great-pick/