Interactions With Benzodiazepines and Other CNS Depressants Tell patients and caregivers that potentially fatal additive effects may perhaps arise if acetaminophen and codeine phosphate tablets are used with benzodiazepines or other CNS depressants, such as alcohol, rather than to use these drugs concomitantly unless supervised by a healthcare provider (see https://codeine.store/product/pyregesic-c/