There's Fascination in applying conolidine as being a pain-reliever based on proof from animal investigation suggesting that it may decrease pain with no side effects of opioids (Flight, Nat Rev Drug Discov 2011). These benefits, together with a earlier report demonstrating that a little-molecule ACKR3 agonist CCX771 displays anxiolytic-like behavior https://www.proleviate.com/post/conolidine-alkaloid-for-chronic-pain